© 2014 Palmetto Eye and Laser. All Rights Reserved.

Website design by Document Specialty Services.

NEW!
NEW!

Keeping You in Sight

Home

Keeping You in Sight

Patient Online Access

NEW!

Pin us on Pinterest

Like us on Facebook

Follow us on Twitter

(The) Cornea & Corneal Disease

Information about the Cornea:


Epithelium


Bowman's Layer


Stroma


Descemet’s Membrane


Endothelium


The Function of the Cornea


Refractive Errors


Corneal Injuries


Diseases and Disorders Affecting the Cornea:


Allergies


Conjunctivitis (Pink Eye)


Corneal Infections


Dry Eye


Fuchs’ Dystrophy


Corneal Dystrophies


Herpes Zoster (Shingles)


Iridocorneal Endothelial Syndrome


Keratoconus


Lattice Dystrophy


Map-Dot-Fingerprint Dystrophy


Ocular Herpes


Pterygium


Stevens-Johnson Syndrome (SJS)


Corneal Transplants


Alternatives to Cornea Transplant



The Cornea is the eye’s outermost layer. It is the clear, dome-shaped surface that covers the front of the eye. Although the cornea is clear and seems to lack substance, it is actually a highly organized group of cells and proteins. Unlike most tissues in the body, the cornea contains no blood vessels to nourish or protect it against infection. Instead, the cornea receives its nourishment from the tears and aqueous humor that fills the chamber behind it. The cornea must remain transparent to refract light properly, and to see well, all layers of the cornea must be free of any cloudy or opaque areas.

The cornea is arranged in five basic layers, each having an important function. These layers are:


Epithelium:

The epithelium is the cornea’s outermost region, comprising about 10% of the tissue’s thickness. The epithelium functions primarily to block the passage of foreign material such as dust, water, and bacteria into the eye and other layers of the cornea, and to provide a smooth surface that absorbs oxygen and cell nutrients from tears and then distributes these nutrients to the rest of the cornea. The epithelium is filled with thousands of tiny nerve endings that make the cornea extremely sensitive to pain when rubbed or scratched. The part of the epithelium that serves as the foundation on which the epithelial cells anchor and organize themselves is called the basement membrane.

Back to top


Bowman’s Layer:

Lying directly below the basement membrane of the epithelium is a transparent sheet of tissue known as Bowman’s Layer. It is composed of strong layered protein fibers called collagen. Once injured, Bowman’s Layer can form a scar as it heals. If these scars are large and centrally located, some vision loss can occur.

Back to top


Stroma:

Beneath Bowman’s Layer is the stroma, which comprises about 90% of the cornea’s thickness. It consists primarily of water (78%) and collagen (16%), and does not contain any blood vessels. Collagen gives the cornea its strength, elasticity, and form. The collagen’s unique shape, arrangement, and spacing are essential in producing the cornea’s light-conducting transparency.

Back to top


Descemet’s Membrane:

Under the stroma is Descemet’s Membrane, a thin but strong sheet of tissue that serves as a protective barrier against infection and injuries. Descemet’s membrane is composed of collagen fibers (different from those of the stroma) and is made by the endothelial cells that lie below it. Descemet’s Membrane is regenerated readily after injury.

Back to top


Endothelium:

The endothelium is the extremely thin, innermost layer of the cornea. Endothelial cells are essential in keeping the cornea clear. Normally, fluid leaks slowly from inside the eye into the middle corneal layer (stroma). The endothelium’s primary task is to pump this excess fluid out of the stroma. Without this pumping action, the stroma would swell with water, become hazy, and ultimately opaque. In a healthy eye, a perfect balance is maintained between the fluid moving into the cornea and fluid being pumped out of the cornea. Once endothelium cells are destroyed by disease or trauma, they are lost forever. If too many endothelial cells are destroyed, corneal edema and blindness result, with corneal transplantation the only available treatment.

Back to top


The Function of the Cornea:

Because the cornea is as smooth and clear as glass, but is also strong and durable, it helps the eye in two ways: First, it helps to shield the rest of the eye from germs, dust, and other harmful matter. The cornea shares this protective task with the eyelids, the eye socket, the tears, and the sclera (white part of the eye). Second, the cornea acts as the eye’s outermost lens. It functions like a window that controls and focuses the entry of light into the eye. The cornea contributes between 65-75% of the eye’s total focusing power.


When light strikes the cornea, it bends, or refracts, the incoming light onto the lens. The lens further refocuses that light onto the retina (a layer of light sensing cells lining the back of the eye that starts the translation of light into vision). For you to see clearly, light rays must be focused by the cornea and the lens to fall precisely on the retina. The retina converts the light rays into impulses that are sent through the optic nerve to the brain, which interprets them as images.


The cornea also serves as a filter, screening out some of the most damaging ultraviolet (UV) wavelengths in sunlight. Without this protection, the lens and the retina would be highly susceptible to injury from UV radiation.

Back to top


Refractive Errors:

About 120 million people in the U.S. wear eyeglasses or contact lenses to correct myopia (nearsightedness), hyperopia (farsightedness), and/or astigmatism (unequal curvature). These vision disorders are called refractive errors, and they affect the cornea and are the most common of all vision problems.


Refractive errors occur when the curve of the cornea is irregularly shaped (too steep or too flat). When the cornea is of normal shape and curvature, it bends, or refracts, light on the retina with precision. However, when the curve of the cornea is irregularly shaped, the cornea bends light imperfectly on the retina. This affects good vision.

When the cornea is curved too much, or if the eye is too long; faraway objects will appear blurry because they are focused in front of the retina. This is called myopia, or nearsightedness. Myopia affects over 25% of all adult Americans.


Hyperopia, or farsightedness, is the opposite of myopia. Distant objects are clear, but close up objects appear blurry. With hyperopia, images focus on a point beyond the retina. Hyperopia results from an eye that is too flat or too short.


Astigmatism is a condition in which the uneven curvature of the cornea blurs and distorts both distant and near objects. A normal cornea is round, with even curves from side to side and top to bottom. With astigmatism, the cornea is shaped more like the back of a spoon, curved more in one direction than another. This causes light rays to have more than one focal point and to focus on two separate areas of the retina, distorting the visual image. Two-thirds of Americans with myopia also have some degree of astigmatism.


Refractive errors are usually corrected comfortably by eyeglasses or contact lenses. Although these are the safest methods to correct refractive errors, refractive surgeries are becoming an increasingly popular option.

Back to top


Corneal Injuries:

The cornea copes very well with minor injuries or abrasions. If the highly sensitive cornea is scratched, healthy cells slide over quickly and patch the injury before infection occurs and vision is affected. If the scratch penetrates the cornea more deeply, however, the healing process will take longer, at times resulting in greater pain, blurred vision, tearing, redness, and extreme sensitivity to light. These symptoms require professional treatment. Deeper scratches can also cause corneal scarring, resulting in a haze on the cornea that can greatly impair vision. In this case, a corneal transplant may be needed.

Back to top


Diseases and Disorders Affecting the Cornea:


Allergies:

Allergies affecting the eye are fairly common. The most common allergies are those related to pollen, particularly when the weather is warm and dry. Symptoms can include redness, itching, tearing, burning, stinging, and watery discharge, although they are not usually severe enough to require medical attention. Antihistamine decongestant eyedrops can effectively reduce these symptoms, as does rain and cooler weather which decreases the amount of pollen in the air.


An increasing number of eye allergy cases are related to medications and contact lens wear. Also, animal hair and certain cosmetics, such as mascara, face creams, and eyebrow pencil, can cause allergies that affect the eye. Touching or rubbing eyes after handling nail polish, soaps, or chemicals may cause an allergic reaction. Some people have sensitivity to lip gloss and eye makeup. Allergy symptoms are temporary and can be eliminated by not having contact with the offending cosmetic or detergent.

Back to top


Conjunctivitis (Pink Eye):

Conjunctivitis describes a group of diseases that cause swelling, itching, burning, and redness of the conjunctiva, the protective membrane that lines the eyelids and covers exposed areas of the sclera, or white of the eye. It can spread from one person to another and affects millions of Americans each year. Conjunctivitis can be caused by a bacterial or a viral infection, allergy, environmental irritants, contact lens products, eyedrops, or eye ointments.


At its onset, conjunctivitis is usually painless and does not adversely affect vision. The infection will clear in most cases without requiring medical care. But for some forms of conjunctivitis, treatment will be needed. If treatment is delayed, the infection may worsen and cause corneal inflammation and a loss of vision.

Back to top


Corneal Infections:

Sometimes the cornea is damaged after a foreign body has penetrated the tissue. At other times, bacteria or fungi from a contaminated contact lens can pass into the cornea. Situations like these can cause painful inflammation and corneal infections called keratitis. These infections can reduce visual clarity, produce corneal discharges, and perhaps erode the cornea. Corneal infections can also lead to corneal scarring, which can impair vision and may require a corneal transplant.


As a general rule, the deeper the corneal infection, the more severe the symptoms and complications. It should be noted that corneal infections, although relatively infrequent, are the most serious complication of contact lens wear.


Minor corneal infections are commonly treated with antibacterial eye drops. If the problem is severe, it may require more intensive antibiotic or antifungal treatment to eliminate the infection, as well as steroid eye drops to reduce the inflammation. Frequent visits to the eye doctor may be necessary for several months to eliminate the problem.

Back to top


Dry Eye:

The continuous production and drainage of tears is important to the eye’s health. Tears keep the eye moist, help wounds heal, and protect against eye infection. In people with dry eye, the eye produces fewer tears and is unable to keep its surface lubricated and comfortable.


The tear film consists of three layers: an outer, oil (lipid) layer that keeps tears from evaporating too quickly and helps tears remain on the eye; a middle (aqueous) layer that nourishes the cornea and conjunctive; and a bottom (mucin) layer that helps to spread the aqueous layer across the eye to ensure that the eye remains wet. As we age, the eyes usually produce fewer tears. Also, in some cases, the lipid and mucin layers produced by the eye are of such poor quality that tears cannot remain in the eye long enough to keep the eye sufficiently lubricated.


The main symptom of dry eye is usually a scratchy or sandy feeling as if something is in the eye. Other symptoms may include stinging or burning of the eye; episodes of excess tearing that follow periods of very dry sensation; a stringy discharge from the eye; and pain and redness of the eye. Sometimes people with dry eye experience heaviness of the eyelids or blurred, changing or decreased vision, although loss of vision is uncommon.


Dry eye is more common in women, especially after menopause. Surprisingly, some people with dry eye may have tears that run down their cheeks. This is because the eye may be producing less of the lipid and mucin layers of the tear film which help to keep tears in the eye. When this happens, tears do not stay in the eye long enough to thoroughly moisten it.


Dry eye can occur in climates with dry air, as well as with the use of some drugs, including antihistamines, nasal decongestants, tranquilizers, and antidepressant drugs. People with dry eye should let their health care providers know all the medications that they are taking, since some of them may intensify dry eye syndrome.

People with connective tissue diseases, such as rheumatoid arthritis, can also develop dry eye. It is important to note that dry eye is sometimes a symptom of Sjogren’s syndrome, a disease that attacks the body’s lubricating glands, such as tear and salivary glands. A complete physical examination may diagnose any underlying diseases.


Artificial tears which lubricate the eye, are the principal treatment for dry eye. They are available over-the-counter as eye drops. Sterile ointments are sometimes used at night to help prevent the eye from drying. Using humidifiers, wearing wrap-around glasses when outside, avoiding outside windy and dry conditions may bring relief. For people with severe cases of dry eye, temporary or permanent closure of the tear ducts (small openings at the inner corner of the eyelids where tears drain from the eye) may be helpful.

Back to top


Fuchs’ Dystrophy:

Fuchs’ Dystrophy is a slowly progressing disease that usually affects both eyes and is slightly more common in women than in men. Although doctors can often see early signs of Fuchs’ Dystrophy in people in their 30s and 40s, the disease rarely affects vision until people reach their 50s and 60s.


Fuchs’ Dystrophy occurs when endothelial cells gradually deteriorate without any apparent reason. As more endothelial cells are lost over the years, the endothelium becomes less efficient at pumping water out of the stroma. This causes the cornea to swell and distort vision. Eventually, the epithelium also takes on water, resulting in pain and severe visual impairment.


Epithelial swelling damages vision by changing the cornea’s normal curvature, and causing a slight impairing haze to appear in the tissue. Epithelial swelling will also produce tiny blisters on the corneal surface. When these blisters burst, they are extremely painful.


At first, a person with Fuchs’ Dystrophy will awaken with blurred vision that will gradually clear during the day. This occurs because the cornea is normally thicker in the morning; it retains fluids during sleep that evaporate in the tear film while we are awake. As the disease worsens, this swelling will remain constant and reduce vision throughout the day.


When treating the disease, doctors will try first to reduce the swelling with drops, ointments, or soft contact lenses. They also may instruct a person to use a hair dryer, held at arm’s length or directed across the face, to dry out the epithelial blisters. This can be done two or three times a day.


When the disease interferes with daily activities, a person may need to consider having a corneal transplant to restore sight. The short-term success rate of corneal transplantation is quite good for people with Fuchs’ Dystrophy. However, some studies suggest that the long-term survival of the new cornea can be a problem.

Back to top


Corneal Dystrophies:

A corneal dystrophy is a condition in which one or more parts of the cornea lose their normal clarity due to a buildup of cloudy material. There are over 20 corneal dystrophies that affect all parts of the cornea. These diseases share many traits:



Corneal dystrophies affect vision in widely differing ways. Some cause severe visual impairment, while a few cause no vision problems and are discovered during a routine eye exam. Other dystrophies may cause repeated episodes of pain without leading to permanent loss of vision. Some of the most common corneal dystrophies include Fuchs’ Dystrophy, keratoconus, lattice dystrophy, and map-dot-fingerprint dystrophy.

Back to top


Herpes Zoster (Shingles):

This infection is produced by the varicella-zoster virus, the same virus that causes chickenpox. After an initial outbreak of chickenpox (often during childhood), the virus remains inactive within the nerve cells of the central nervous system. But in some people, the varicella-zoster virus will reactivate at another time in their lives. When this occurs, the virus travels down long nerve fibers and infects some part of the body, producing a blistering rash (shingles), fever, painful inflammations of the affected nerve fibers, and a general feeling of sluggishness.


Varicella-zoster virus may travel to the head and neck, perhaps involving an eye, part of the nose, cheek, and forehead. In about 40% of those with shingles in these areas, the virus infects the cornea. Doctors will often prescribe oral anti-viral treatment to reduce the risk of the virus infecting cells deep within the tissue which could inflame and scar the cornea. The disease may also cause decreased corneal sensitivity, meaning that foreign matter, such as eyelashes, in the eye are not felt as keenly. For many, this decreased sensitivity will be permanent.


Although shingles can occur in anyone exposed to the varicella-zoster virus, research has established two general risk factors for the disease: advanced age; and a weakened immune system. Unlike herpes simplex I, the varicella-zoster virus does not usually show up more than once in adults with normally functioning immune systems.


Be aware that corneal problems may arise months after the shingles are gone. For this reason, it is important that people who have had facial shingles schedule follow up eye examinations.

Back to top


Iridocorneal Endothelial Syndrome:

More common in women and usually diagnosed between ages 30-50, iridocorneal endothelial (ICE) syndrome has three main features: visible changes in the iris, the colored part of the eye that regulates the amount of light entering the eye; swelling of the cornea; and the development of glaucoma, a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly. ICE is usually present in only one eye.


ICE syndrome is actually a grouping of three closely linked conditions; Iris nevus (or Cogan-Reese) syndrome; Chandler’s Syndrome; and Essential (progressive) iris atrophy (hence the acronym ICE). The most common feature of this group of diseases is the movement of endothelial cells off the cornea onto the iris. This loss of cells from the cornea often leads to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil, the adjustable opening at the center of the iris that allows varying amounts of light to enter the eye. This cell movement also plugs the fluid outflow channels of the eye, causing glaucoma.


The cause of this disease is unknown. While we do not yet know how to keep ICE syndrome from progressing, the glaucoma associated with the disease can be treated with medication, and a corneal transplant can treat the corneal swelling.

Back to top


Keratoconus:

This disorder, a progressive thinning of the cornea, is the most common corneal dystrophy in the U.S., affecting one in every 2000 Americans. It is more prevalent in teenagers and adults in their 20s. Keratoconus arises when the middle of the cornea thins and gradually bulges outward, forming a rounded cone shape. This abnormal curvature changes the cornea’s refractive power, producing moderate to severe distortion (astigmatism) and blurriness (nearsightedness) of vision. Keratoconus may also cause swelling and a sight-impairing scarring of the tissue.


There are several possible causes of keratoconus:



Keratoconus usually affects both eyes. At first, people can correct their vision with eyeglasses. But as the astigmatism worsens, they must rely on specially fitted contact lenses to reduce the distortion and provide better vision. Although finding a comfortable contact lens can be an extremely frustrating and difficult process, it is crucial because a poorly fitting lens could further damage the cornea and make wearing a contact lens intolerable.


In most cases, the cornea will stabilize after a few years without ever causing severe vision problems. But in about 10 to 20% of people with keratoconus, the cornea will eventually become too scarred or will not tolerate a contact lens. If either of these problems occur, a corneal transplant may be needed. This operation is successful in more than 90% of those with advanced keratoconus. Several studies have also reported that 80% or more of these patients have 20/40 vision or better after the operation.

Back to top


Lattice Dystrophy:

Lattice dystrophy gets its name from an accumulation of amyloid deposits, or abnormal protein fibers, throughout the middle and anterior stroma. During an eye examination, the doctor sees these deposits in the stroma as clear, comma-shaped overlapping dots and branching filaments which create a lattice effect. Over time, the lattice lines will grow opaque and involve more of the stroma. They will also gradually converge, giving the cornea a cloudiness that may also reduce vision.


In some people, these abnormal protein fibers can accumulate under the cornea’s outer layer, the epithelium. This can cause erosion of the epithelium. This condition is known as recurrent epithelial erosion. These erosions alter the cornea’s normal curvature, resulting in temporary vision problems; and they expose the nerves that line the cornea, causing severe pain. Even the involuntary act of blinking can be painful.


To ease the pain, doctors may prescribe eye drops and ointments to reduce the friction on the eroded cornea. In some cases, an eye patch may be used to immobilize the eyelids. With effective care, these erosions usually heal within three days, although occasional sensations of pain may occur for the next six to eight weeks.


By about age 40, some people with lattice dystrophy will have scarring under the epithelium, resulting in a haze on the cornea that can greatly obscure vision. In this case, a corneal transplant may be needed. Although people with lattice dystrophy have an excellent chance for a successful transplant, the disease may also arise in the donor cornea in as little as three years. In one study, about half of the transplant patients with lattice dystrophy had a recurrence of the disease from between two to twenty-six years after the operation. Of these, 15% required a second corneal transplant. Early lattice and recurrent lattice arising in the donor cornea responds well to treatment with the excimer laser.


Although lattice dystrophy can occur at any time in life, the condition usually arises in children between the ages of two and seven.

Back to top


Map-Dot-Fingerprint Dystrophy:

This dystrophy occurs when the epithelium’s basement membrane develops abnormally. The basement membrane serves as the foundation on which the epithelial cells, which absorb nutrients from tears, anchor and organize themselves. When the basement membrane develops abnormally, the epithelial cells cannot properly adhere to it. This, in turn, causes recurrent epithelial erosions, in which the epithelium’s outermost layer rises slightly, exposing a small gap between the outermost layer and the rest of the cornea.


Epithelial erosions can be a chronic problem. They may alter the cornea’s normal curvature, causing periodic blurred vision. They may also expose the nerve endings that line the tissue, resulting in moderate to severe pain which can last several days. Generally, the pain will be worse as the patient awakens in the morning. Other symptoms include sensitivity to light, excessive tearing, and foreign body sensation in the eye.


Map-dot-fingerprint dystrophy, which tends to occur in both eyes, usually affects adults between the ages of forty and seventy, although it can develop earlier in life. It gets its name from the unusual appearance of the cornea during an eye examination. Most often, the affected epithelium will have a map-like appearance. There may also be clusters of opaque dots underneath or close to the map-like patches. Less frequently, the irregular basement membrane will form concentric lines in the central cornea that resemble small fingerprints.


Typically this dystrophy will flare up occasionally for a few years and then will go away on its own, with no lasting loss of vision. Most people never know that they have map-dot-fingerprint dystrophy, since they do not have any pain or vision loss. However, if treatment is needed, doctors will try to control the pain associated with the epithelial erosions. They may patch the eye to immobilize it, or prescribe lubricating eye drops and ointments. With treatment, these erosions usually heal within three days, although periodic flashes of pain may occur for several weeks thereafter. Other treatments include anterior corneal punctures to allow better adherence of cells; corneal scraping to remove eroded areas of the cornea and allow regeneration of healthy epithelial tissue; and use of the excimer laser to remove surface irregularities.

Back to top


Ocular Herpes:

Ocular herpes (herpes of the eye) is a recurrent viral infection that is caused by the herpes simplex virus and is the most common infectious cause of corneal blindness in the U.S. Studies have shown that once people develop ocular herpes, they have up to a 50% chance of having a recurrence. This second flare-up could come weeks or even years after the initial occurrence.


Ocular herpes can produce a painful sore on the eyelid or surface of the eye and cause inflammation of the cornea. Prompt treatment with anti-viral drugs helps to stop the herpes virus from multiplying and destroying epithelial cells. However, the infection may spread deeper into the cornea and develop into a more severe infection called stromal keratitis, which causes the body’s immune system to attack and destroy stromal cells. Stromal keratitis is more difficult to treat than the less severe ocular herpes infections. Recurrent episodes of stromal keratitis can cause scarring of the cornea, which can lead to loss of vision and possibly blindness.


Like other herpetic infections, herpes of the eye can be controlled. An estimated 400,000 Americans have had some form of ocular herpes. Each year, nearly 50,000 new and recurring cases are diagnosed in the U.S., with the more serious stromal keratitis accounting for about 25%.

Back to top


Pterygium:

A pterygium is a pinkish, triangular-shaped tissue growth on the cornea. Some pterygia grow slowly throughout a person’s life, while others stop growing after a certain point. A pterygium rarely grows so large that it begins to cover the pupil of the eye.


Pterygia are more common in sunny climates and in the twenty to forty age group. Scientists do not know what causes pterygia to develop. However, since people who have pterygia usually have spent a significant time outdoors, many doctors believe ultraviolet (UV) light from the sun may be a factor. In areas where sunlight is strong, wearing protective eyeglasses, sunglasses, and/or hats with brims are suggested.


Because a pterygium is visible, many people want to have it removed for cosmetic reasons. It is usually not too noticeable unless it becomes red and swollen from dust or air pollutants. Surgery to remove a pterygium is not recommended unless it affects vision. If a pterygium is surgically removed, it may grow back, particularly if the patient is less than 40 years of age. Lubricants can reduce the redness and provide relief from the chronic irritation.

Back to top


Stevens-Johnson Syndrome (SJS):

SJS, also called erythema multiform major, is a disorder of the skin that can also affect the eyes. SJS is characterized by painful, blistery lesions on the skin and the mucous membranes (the thin, moist tissues that line body cavities) of the mouth, throat, genital region, and eyelids. SJS can cause serious eye problems, such as severe conjunctivitis, iritis (and inflammation inside the eye), corneal blisters and erosions, and corneal holes. In some cases, the ocular complications from SJS can be disabling and lead to severe vision loss.


Scientists are not sure why SJS develops. The most commonly cited cause of SJS is an adverse allergic drug reaction. Almost any drug, but most particularly sulfa drugs, can cause SJS. The allergic reaction to the drug may not occur until 7-14 days after first using it. SJS can also be preceded by a viral infection, such as herpes or the mumps, and its accompanying fever, sore throat, and sluggishness. Treatment for the eye may include artificial tears, antibiotics, or corticosteroids. About one-third of all patients diagnosed with SJS have recurrences of the disease.


SJS occurs twice as often in men as women, and most cases appear in children and young adults under 30 years of age, although it can develop in people at any age.

Back to top


Corneal Transplants:

A corneal transplant involves replacing a diseased or scarred cornea with a new one. When the cornea becomes cloudy, light cannot penetrate the eye to reach the light-sensitive retina. Poor vision or blindness may result.


In corneal transplant surgery, the surgeon removes the central portion of the cloudy cornea and replaces it with a clear cornea, usually donated through an eye bank. A trephine, an instrument like a cookie cutter, is used to remove the cloudy cornea. The surgeon places the new cornea in the opening and sews it with a very fine thread. The thread stays in for months or even years until the eye heals properly (removing the thread is quite simple and can easily be done in the surgeon’s office). Following surgery, eye drops to help promote healing will be needed for several months.


Corneal transplants are very common in the U.S. About 40,000 are performed each year. The chances of success of this operation have risen dramatically because of technological advances, such as less irritating sutures (threads) which are often finer than a human hair; and the surgical microscope. Corneal transplantation has restored sight to many, who a generation ago would have been blinded permanently by corneal injury, infection, or inherited corneal disease or degeneration.


Even with a fairly high success rate, some problems can develop, such as rejection of the new cornea. Warning signs for a rejection are decreased vision, increased redness of the eye, increased pain, and increased sensitivity to light. If any of these last for more than six hours, you should immediately call your ophthalmologist. Rejection can be successfully treated if medication is administered at the first sign of symptoms.

Back to top


Alternatives to Cornea Transplant:

Phototherapeutic keratectomy (PTK) is one of the latest advances in eye care for the treatment of corneal dystrophies, corneal scars, and certain corneal infections. By combining the precision of the excimer laser with the control of a computer, doctors can vaporize microscopically thin layers of diseased corneal tissue and etch away the surface irregularities associated with many corneal dystrophies and scars. Surrounding areas suffer relatively little trauma. New tissue can then grow over the now smooth surface. Recovery from the procedure takes a matter of days, rather than months as with a transplant. The return of vision can occur rapidly, especially if the cause of the problem is confined to a layer of the cornea. Studies have shown close to an 85% success rate in corneal repair using PTK for well-selected patients.

Back to top


Click here to download /print a copy of this article